Structural analysis of brain ganglioside acetylation patterns in mice with altered ganglioside biosynthesis
نویسندگان
چکیده
منابع مشابه
Combinatorial ganglioside biosynthesis.
Ganglioside Structure and Function Sphingolipids are building blocks of eukaryotic cell surfaces (1). They anchor lipid-bound carbohydrates to the plasma membrane and contribute to the epidermal water permeability barrier of the skin. Glycolipid patterns can reach a high degree of complexity that constitutes a paradigm of combinatorial biosynthesis. During combinatorial biosynthesis, a variety ...
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Chemicaly and x-ray-transformed subclones of BALB/c 3T3 mouse embryo cells were found to have reduced amounts of the mono- and disialogangliosides galactosyl-N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylceramide (Gm1) and N-acetylneuraminylgalactosyl-N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylceramide (Gd1a), and increased amounts of N-acetylgalactosaminyl-[N...
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GD3 synthase is rapidly activated in different cell types after specific apoptotic stimuli. De novo synthesized GD3 accumulates and contributes to the apoptotic program by relocating to mitochondrial membranes and inducing the release of apoptogenic factors. We found that sialic acid acetylation suppresses the proapoptotic activity of GD3. In fact, unlike GD3, 9-O-acetyl-GD3 is completely ineff...
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extractability of phylloerythrin from bile was tested by adding fresh ox bile to equal volumes of buffer solutions and shaking with ether. In solutions below pH 5 almost all the phylloerythrin was extracted into the ether. Above pH 7-5 less than 5% of the phylloerythrin was present in the ether phase. Between pH 5 and 7-5 intermediate values were obtained. This behaviour could be imitated by ad...
متن کاملRegulation of ganglioside biosynthesis in the nervous system.
Ganglioside biosynthesis is strictly regulated by the activities of glycosyltransferases and is necessarily controlled at the levels of gene transcription and posttranslational modification. Cells can switch between expressing simple and complex gangliosides or between different series within these two groups during brain development. The sequential biosynthesis of gangliosides in parallel enzy...
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ژورنال
عنوان ژورنال: Carbohydrate Research
سال: 2013
ISSN: 0008-6215
DOI: 10.1016/j.carres.2013.09.007